George Clooney’s Busy Career, Jet-Setting Lifestyle Has ‘Cost Him a Lot, Physically and Emotionally’

George Clooney is raising fears he’s putting his health in jeopardy with his relentless schedule after skipping several events at the Venice Film Festival due to illness, sources tell Globe.

The sinus infection that forced the burned-out 64-year-old actor from promoting his upcoming Netflix movie Jay Kelly is a sign of a much more serious problem than a mere case of the sniffles, an insider says.

“George has so much going on he rarely gets a night off,” the insider says. “That schedule might have been doable at 45, but he’s not a young man anymore. He’s got to learn to take his foot off the pedal, no matter how hard that is for someone like him to do. Otherwise, you start getting sick and that could lead to serious problems with a bit of bad luck.”

Doctors tell Globe that minor illnesses like a sinus infection are often an ominous sign the body needs rest and a chance to recuperate.

“It’s a message you ignore at your peril,” Florida aging expert Dr. Gabe Mirkin, who hasn’t treated George, tells Globe. “At his age, you need to give yourself a break or you risk more serious illness.”

The ER alum’s typically hectic schedule has been even more intense lately, sources say.

Incredibly, this spring he shot Jay Kelly at roughly the same time that he rehearsed and performed in the Broadway hit Good Night, and Good Luck.

The Ocean’s Eleven star has also been criss-crossing the globe to spend time with his 8-year-old twins, Alexander and Ella, and convince his skeptical wife, Amal, 47, he’s not an absentee father.

“I don’t know how he does it,” admits a source. “But it’s cost him a lot, physically and emotionally and mentally.”

Insiders say while the activist actor has cut back on Democratic Party fundraising efforts over feeling scapegoated for Kamala Harris’ 2024 election defeat — after he torpedoed incumbent Joe Biden’s presidential bid with a scathing New York Times op-ed — he’s still heavily invested in political kingmaking.

According to our source, he hasn’t entirely ruled out running for president himself — if he can figure out a healthier work-life balance.